human ADD1 Over-expression AAV

Name 
AAV-h-ADD1
Cat No 
AAV-200440
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ADD1.

AAV-200440
AAV-h-ADD1

Ready-to-use AAV expressing Human ADD1 (adducin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ADDA; adducin 1 (alpha); alpha-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
Description (eCommerce)
Alpha-adducin is a member of the adducin family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C [taken from NCBI Entrez Gene (Gene ID: 118)].
Description (Vector)
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
Gene ID
118
Gene Name (eCommerce)
adducin 1
Gene Name (Vector)
adducin 1
Gene Symbol
ADD1
HGNC ID
HGNC:243
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1989
ORF Size (bp)
1989 bp
Protein Name (eCommerce)
Alpha-adducin
RefSeq ID
NM_001119
RefSeq Synonyms
NM_176801, NM_014190, NM_014189, NM_001286645, NM_001119, BC042998, BC013393,
Research Areas
Apoptosis,Cytoskeleton,Immunology,Neurobiology,Synapse,T-cell Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Alpha-adducin is a member of the adducin family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C [taken from NCBI Entrez Gene (Gene ID: 118)].
UniGene ID
Hs.701490
UniProt ID (eCommerce)
P35611

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.