AAV-GFP-iCre (AAV2) AAV
By applying the mammalian codon usage to Cre recombinase, expression of Cre is improved in the mammalian cells. This improved Cre (iCre) gene also reduce the high CpG content of the prokaryotic coding sequence, thereby reducing the chances of epigenetic silencing in mammals.
This AAV2 stock expresses an improved Cre (iCre) along with an eGFP under a control of the same CMV promoter. The Cre and eGFP was separated by a 2A peptides.
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- Viral Backbone
- Recombinant AAV
- AAV Serotype
- CMV (ubiquitous)
- Storage Buffer
- PBS/5% Glycerol
- 1x10^13 GC/ml
- Gene Symbol
- improved Cre (iCre)
This product is referenced in the following publications:
- CE Mac Nair, etc (2016). Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways. Journal of Neuroinflammation.
- M Harun-Or-Rashid, etc (2020). MCT2 Overexpression Rescues Metabolic Vulnerability and Protects Retinal Ganglion Cells in Two Models of Glaucoma. bioRxiv.