AAV-Cre (AAV serotype 5) AAV
Cre recombinase is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DNA between loxP sites. loxP is a 34 bp DNA sequence at which confers directionality. Cre recombinase is used as a tool to genetically modify genes, such as to delete a segment of DNA flanked by LoxP sites in cultured cells or experimental animals.
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- Viral Backbone
- Recombinant AAV
- AAV Serotype
- CMV (ubiquitous)
- Storage Buffer
- PBS/5% Glycerol
- 1x10^13 GC/ml
- Gene Symbol
- Cre Recombinase
This product is referenced in the following publications:
- Anthony, TE. etc (2014). Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit. Cell.
- Gonzalo Viana Di Prisco, etc (2014). Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nature Neuroscience.
- Melanie A Samuel, etc (2014). LKB1 and AMPK regulate synaptic remodeling in old age. Nature Neuroscience.
- W Huang, etc (2016). Translational control by eIF2a phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine. eLife.
- von Schimmelmann M, etc (2016). Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nat Neurosci.
- Placzek AN, etc (2016). eIF2a-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. eLife.
- L Sun, etc (2020). Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin.
- D Kargl, etc (2020). The amygdala instructs insular feedback for affective learning. eLIFE.