AAV-Cre (AAV serotype 1) AAV
Category: AAV > Over-Expression > Cre Recombinases
Cat. No: 7010
This AAV serotype 1 virus (with Capsid from AAV1 and ITR from AAV2) expresses Cre Recombinase under the control of a CMV promoter. This Cre contains a nuclear localization signal (NLS).
Cre recombinase is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DNA between loxP sites. loxP is a 34 bp DNA sequence at which confers directionality. Cre recombinase is used as a tool to genetically modify genes, such as to delete a segment of DNA flanked by LoxP sites in cultured cells or experimental animals.
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- Viral Backbone
- Recombinant AAV
- AAV Serotype
- CMV (ubiquitous)
- Storage Buffer
- PBS/5% Glycerol
- 1x10^13 GC/ml
- Gene Symbol
- Cre Recombinase
This product is referenced in the following publications:
- Zita Rovó, etc (2014). Phasic, Nonsynaptic GABA-A Receptor-Mediated Inhibition Entrains Thalamocortical Oscillations. Journal of Neuroscience.
- K Du, etc (2015). Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury. Journal of Neuroscience.
- BJ Hilton, etc (2016). Re-Establishment of Cortical Motor Output Maps and Spontaneous Functional Recovery via Spared Dorsolaterally Projecting Corticospinal Neurons after Dorsal Column Spinal Cord Injury in Adult Mice. The Journal of Neuroscience.
- Antoine MW, etc (2017). The severity of vestibular dysfunction in deafness as a determinant of comorbid hyperactivity or anxiety. Journal of NeuronScience.
- B Lee, etc (2018). Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Molecular Neurobiology.
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