mouse LMNA shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown mouse LMNA gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this mouse gene was validated by western blot in C2C12 cells.
1847
Ad-m-LMNA-shRNA
Ready-to-use mouse LMNA shRNA Adenovirus. mouse LMNA shRNA adenovirus gene knockdown1847
Gene Reference Data
Alternate Names
Dhe
Description (Vector)
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics|Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Gene ID
16905
Gene Name (Vector)
lamin A
Gene Symbol
Lmna
ORF Size (aa)
1998
ORF Size (bp)
1998 bp
RefSeq ID
NM_001002011
RefSeq Synonyms
NM_019390, NM_001111102, NM_001002011, BC094020, BC015302,
Species
mouse
UniGene ID
Mm.471227
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.