human IKKb shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human IKKb gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by western blot in A549 cells.
1842
Ad-h-IKKb-shRNA
Ready-to-use human IKKb shRNA Adenovirus. human IKKb shRNA adenovirus gene knockdown1842
Gene Reference Data
Alternate Names
I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK2; IKKB; IKK-B; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta
Description (eCommerce)
IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.
Description (Vector)
IKBKB phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
Gene ID
3551
Gene Name (eCommerce)
inhibitor of nuclear factor kappa B kinase subunit beta
Gene Name (Vector)
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene Symbol
IKBKB
HGNC ID
HGNC:5960
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1263
ORF Size (bp)
1263 bp
Protein Name (eCommerce)
Inhibitor of nuclear factor kappa-B kinase subunit beta
RefSeq ID
NM_001556
RefSeq Synonyms
NM_001556, NM_001242778, NM_001190720, BC108694,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Cytokine Signaling,EPO Signaling,Fc Receptor Signaling,FoxO Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,mTOR Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PI3K/Akt Signaling,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,Transcription Factor/Regulator,TSH Signaling,TWEAK Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.
UniGene ID
Hs.597664
UniProt ID (eCommerce)
O14920
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.