human FADD shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human FADD gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by western blot in A549 cells.
1831
Ad-h-FADD-shRNA
Ready-to-use human FADD shRNA Adenovirus. human FADD shRNA adenovirus gene knockdown1831
Gene Reference Data
Alternate Names
GIG3; MORT1
Description (Vector)
FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Gene ID
8772
Gene Name (Vector)
Fas associated via death domain
Gene Symbol
FADD
HGNC ID
HGNC:3573
ORF Size (aa)
627
ORF Size (bp)
627 bp
RefSeq ID
NM_003824
RefSeq Synonyms
NM_003824, BC000334,
Species
human
UniGene ID
Hs.86131
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.