mouse CD4 shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown mouse CD4 gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this mouse gene was validated by qPCR in mouse CD4-T-cells cells.
1822
Ad-m-CD4-shRNA
Ready-to-use mouse CD4 shRNA Adenovirus. mouse CD4 shRNA adenovirus gene knockdown1822
Gene Reference Data
Alternate Names
CD antigen CD4; L3T4; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Description (eCommerce)
CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. CD4 is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system [taken from NCBI Entrez Gene (Gene ID: 920)].
Description (Vector)
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Gene ID
12504
Gene Name (eCommerce)
CD4 antigen
Gene Name (Vector)
CD4 antigen
Gene Symbol
Cd4
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
Protein Name (eCommerce)
T-cell surface glycoprotein CD4
RefSeq ID
NM_013488
RefSeq Synonyms
NM_013488, BC039137,
Research Areas
Antigen Processing and Presentation,Apoptosis,Host-Virus Interactions,Immune Cells and Tumor Markers,Immunology,Immuno-Oncology,Innate Immunity,Interleukin Signaling,NF-kB Signaling,Signal Transduction,immunology,cell_biology,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immuno_oncology,immunology,infectious_disease,signal_transduction
Species
mouse
Target Sentence
CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. CD4 is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system [taken from NCBI Entrez Gene (Gene ID: 920)].
UniGene ID
Mm.2209
UniProt ID (eCommerce)
P06332
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.