human CASP3 shRNA Adenovirus

apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1

Caspase 3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. Caspase 3 is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease [taken from NCBI Entrez Gene (Gene ID: 836)].

CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

836

caspase 3

caspase 3

CASP3

HGNC:1504

9606.0

834

834 bp

Caspase-3

NM_004346

NM_032991, NM_004346, BC016926,

Alzheimer's Disease,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,BDNF Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,CD95/FAS Signaling,Cell Cycle,Colorectal Cancer,Cytoskeleton,DNA Damage/Repair,Hippo Signaling,Host-Virus Interactions,Huntington's Disease,Immunology,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,NFAT Signaling,NGF Signaling,p53 Signaling,Parkinson's Disease,Prolactin Signaling,Prostate Cancer,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Translational Control,TWEAK Signaling,Viral Carcinogenesis

cancer,genetics,signal_transduction,neurobiology,cell_biology,signal_transduction,immunology,cardiovascular,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,neurobiology,immunology,signal_transduction,cell_biology,metabolism,neurobiology,developmental_biology,signal_transduction,neurobiology,immunology,genetics,transcription_translation,cancer,infectious_disease

human

Caspase 3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. Caspase 3 is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease [taken from NCBI Entrez Gene (Gene ID: 836)].

Hs.141125

P42574