human BCR shRNA Adenovirus

Name 
Ad-h-BCR-shRNA
Cat No 
1809
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human BCR gene. The shRNA expression is driven by an U6 promoter.

The knockdown of this human gene was validated by qPCR in A549 cells.

1809
Ad-h-BCR-shRNA

Ready-to-use human BCR shRNA Adenovirus. human BCR shRNA adenovirus gene knockdown1809

$995.00
Request Volume Pricing or Customization

Product Details

Promoter
U6 ()
Reporter
eGFP
shRNA Knockdown (%)
89
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ALL; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region protein; CML; D22S11; D22S662; FGFR1/BCR chimera protein; PHL; renal carcinoma antigen NY-REN-26
Description (eCommerce)
BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.
Gene ID
613
Gene Name (eCommerce)
BCR, RhoGEF and GTPase activating protein
Gene Symbol
BCR
NCBI Taxonomy ID (eCommerce)
9606.0
Protein Name (eCommerce)
Breakpoint cluster region protein
RefSeq ID
NM_004327
RefSeq Synonyms
NM_021574, NM_004327,
Research Areas
B-cell Receptor Signaling,Brain Development,Cancer,Cell Cycle,Cytoskeleton,FGF Signaling,Immunology,Kinase/Phosphatase,Leukemia,Neurobiology,Neurodevelopment,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.
UniProt ID (eCommerce)
P11274

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.