Cell division cycle 25C Adenovirus

Name 
Ad-Cdc25C
Cat No 
1598
Availability
Immediate
Categories
Adenovirus, Over-Expression

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest.

1598
Ad-Cdc25C

Ready-to-use Cell division cycle 25C Adenovirus. Ad-Cdc25C, Cell division cycle 25C, CDC25, CDC25C adenovirus 1598

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CDC25; dual specificity phosphatase CDC25C; mitosis inducer CDC25; M-phase inducer phosphatase 3; phosphotyrosine phosphatase; PPP1R60; protein phosphatase 1, regulatory subunit 60
Description (eCommerce)
CDC25c (cell division cycle 25 homolog c) is a member of the Cdc25 family of phosphatases. CDC25c promotes cell cycle progression and M-phase entry by dephosphorylating CDC2/cyclin B and activating its kinase activity. CDC25c is phosphorylated and activated by multiple kinases including chk1, Cdc2/cyclin B, polo-like kinase 1, and JNK MAP kinases. The inactivation of CDC25c phosphatase activity is achieved through dephosphorylation by PP1 and PP2A phosphatases.
Description (Vector)
CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
Gene ID
995
Gene Name (eCommerce)
cell division cycle 25C
Gene Name (Vector)
cell division cycle 25C
Gene Symbol
CDC25C
HGNC ID
HGNC:1727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1422
ORF Size (bp)
1422 bp
Protein Name (eCommerce)
M-phase inducer phosphatase 3
RefSeq ID
NM_001790
RefSeq Synonyms
NM_022809, NM_001790, NM_001318098, NM_001287583, NM_001287582, BC019089,
Research Areas
Cancer,Cell Cycle,Cell Division,DNA Damage/Repair,DNA Replication,Host-Virus Interactions,Kinase/Phosphatase,Meiosis,MicroRNAs in Cancer,Phosphatase,PLK1 Signaling,Replication,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
CDC25c (cell division cycle 25 homolog c) is a member of the Cdc25 family of phosphatases. CDC25c promotes cell cycle progression and M-phase entry by dephosphorylating CDC2/cyclin B and activating its kinase activity. CDC25c is phosphorylated and activated by multiple kinases including chk1, Cdc2/cyclin B, polo-like kinase 1, and JNK MAP kinases. The inactivation of CDC25c phosphatase activity is achieved through dephosphorylation by PP1 and PP2A phosphatases.
UniGene ID
Hs.656
UniProt ID (eCommerce)
P30307

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.