v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) Adenovirus

Name 
Ad-ETS-1
Cat No 
1597
Availability
Immediate
Categories
Adenovirus, Over-Expression

The Ets family of transcription factors are DNA-binding proteins implicated in lymphoid development and activity. This family includes Ets-1, Ets-2, Erg-1-3, Elk-1, ETV-1, Elf-1, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A and Net. They are characterized as monomeric transcription factors that bind the DNA site GGA(A/T) through a unique winged helix-turn-helix motif known as the Ets domain. The ability of Ets transcription factors to bind DNA and activate transcription is regulated through phosphorylation. PU.1 transcription factors, including Spi-1, Spi-B and Spi-C, are closely related Ets family members that share a conserved divergent sequence within the Ets domain, which enables them to bind to AGAA sites.

1597
Ad-ETS-1

Ready-to-use v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) Adenovirus. Ad-ETS-1, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian), ETS1, ETS-1, EWSR2 adenovirus 1597

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; c-ets-1; ETS-1; EWSR2; p54; protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1
Description (eCommerce)
Ets-1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 2113)].
Description (Vector)
ETS1 encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
2113
Gene Name (eCommerce)
ETS proto-oncogene 1, transcription factor
Gene Name (Vector)
ETS proto-oncogene 1, transcription factor
Gene Symbol
ETS1
HGNC ID
HGNC:3488
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
819
ORF Size (bp)
819 bp
Protein Name (eCommerce)
Protein C-ets-1
RefSeq ID
NM_005238
RefSeq Synonyms
NM_005238, NM_001330451, NM_001162422, NM_001143820, BC017314,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,Cancer,Cardiovascular,Cell Cycle,FGF Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,Kidney Cancer,Neurobiology,Neurodevelopment,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Ets-1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 2113)].
UniGene ID
Hs.369438
UniProt ID (eCommerce)
P14921

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.