Beta-site APP-cleaving enzyme 2 Adenovirus

Name 
Ad-BACE2
Cat No 
1596
Availability
Immediate
Categories
Adenovirus, Over-Expression

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer’s disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the ‘Down critical region’ of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.

1596
Ad-BACE2

Ready-to-use Beta-site APP-cleaving enzyme 2 Adenovirus. Ad-BACE2, Beta-site APP-cleaving enzyme 2, ASP1,BAE2,DRAP,AEPLC,ALP56,ASP21,BACE2,CDA13,CEAP1 adenovirus 1596

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Description (Vector)
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Gene ID
25825
Gene Name (Vector)
beta-site APP-cleaving enzyme 2
Gene Symbol
BACE2
HGNC ID
HGNC:934
ORF Size (aa)
1557
ORF Size (bp)
1557 bp
RefSeq ID
NM_012105
RefSeq Synonyms
NM_138992, NM_138991, NM_012105, BC014453,
Species
human
UniGene ID
Hs.529408

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.