Retinoid X receptor, gamma Adenovirus

Name 
Ad-RXRg
Cat No 
1590
Availability
Immediate
Categories
Adenovirus, Over-Expression

Retinoids are metabolites of vitamin A (retinol) that represent an important group of signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) include RARα, RARβ and RARγ, each of which has a high affinity for all transretinoic acids. Members of the retinoid X receptor (RXR) family, RXRα, RXRβ1, RXRβ2 and RXRγ, are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all transretinoic acids that is expressed in vivo in both liver and kidney and may represent a widely used hormone. The RAR-related orphan nuclear receptors (ROR) bind DNA as monomers and include RORα, RORβ and RORγ. DAX-1 binds to retinoic acid response elements to mediate transcription. FXR (activated by farnesol and related metabolites) binds RXR to form a heterodimer, which subsequently binds IR-1 elements.

1590
Ad-RXRg

Ready-to-use Retinoid X receptor, gamma Adenovirus. Ad-RXRg, “Retinoid X receptor, gamma”, RXRC, RXRG, NR2B3, RXRgamma, RXR-gamma adenovirus 1590

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
NR2B3; RXRC
Description (Vector)
RXRG encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXRG is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
Gene ID
6258
Gene Name (Vector)
retinoid X receptor gamma
Gene Symbol
RXRG
HGNC ID
HGNC:10479
ORF Size (aa)
1392
ORF Size (bp)
1392 bp
RefSeq ID
NM_006917
RefSeq Synonyms
NM_006917, NM_001256571, NM_001256570, BC012063,
Species
human
UniGene ID
Hs.26550

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.