Dual specificity phosphatase 4 Adenovirus
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4.
Ready-to-use Dual specificity phosphatase 4 Adenovirus. Ad-MKP2, Dual specificity phosphatase 4, TYP, HVH2, MKP2, DUSP4, MKP-2 adenovirus 1574
Gene Reference Data
Related Citations
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- Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Balko, JM. etc, (2012), Nature Medicine
- Glutathione Peroxidase-1 (GPx-1) deficiency augments pro-inflammatory cytokine-induced redox signaling and human endothelial cell activation. Lubos, etc, (2011), J Biol Chem