Retinoic acid receptor, alpha Adenovirus

Name 
Ad-RARa
Cat No 
1544
Availability
Immediate
Categories
Adenovirus, Over-Expression

Retinoids are metabolites of vitamin A (retinol) that represent an important group of signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) include RAR-alpha, RAR-beta and RAR-gamma, each of which has a high affinity for all transretinoic acids. Members of the retinoid X receptor (RXR) family, RXR-alpha, RXR-beta1, RXR-beta2 and RXR-gamma, are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all transretinoic acids that is expressed in vivo in both liver and kidney and may represent a widely used hormone. The RAR-related orphan nuclear receptors (ROR) bind DNA as monomers and include ROR-alpha, ROR-beta and ROR-gamma. DAX-1 binds to retinoic acid response elements to mediate transcription. FXR (activated by farnesol and related metabolites) binds RXR to form a heterodimer, which subsequently binds IR-1 elements.

1544
Ad-RARa

Ready-to-use Retinoic acid receptor, alpha Adenovirus. Ad-RAR-A, “Retinoic acid receptor, alpha”, RAR, RARA, NR1B1 adenovirus 1544

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
NR1B1; RAR
Description (Vector)
RARA represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. RARA has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Gene ID
5914
Gene Name (Vector)
retinoic acid receptor alpha
Gene Symbol
RARA
HGNC ID
HGNC:9864
ORF Size (aa)
1389
ORF Size (bp)
1389 bp
RefSeq ID
NM_000964
RefSeq Synonyms
NM_001145302, NM_001145301, NM_001024809, NM_000964, BC071733, BC008727,
Species
human
UniGene ID
Hs.654583

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.