Protein tyrosine phosphatase, non-receptor type 6 Adenovirus

Name 
Ad-PTP1C
Cat No 
1540
Availability
Immediate
Categories
Adenovirus, Over-Expression

Protein phosphatases play critical roles in the regulation of signal transduction pathways. The family can be separated into three general categories, which are distinguished on the basis of substrate specificity. The first and largest category, termed protein tyrosine phosphatases or PTPs, includes transmembrane proteins, membrane associated proteins and proteins that localize to nuclei. Transmembrane PTPs are involved in homophilic binding and facilitate cell-cell communication. Membrane associated PTPs include the following proteins SH-PTP1 (PTP1C, HCP, SHP), SH-PTP2 (Syp, PTP1D), PTP-H1 and PTP1B. Fap-1 (also designated PTP-BAS) contains an ezrin-like membrane binding domain and through its association with FAS presumably regulates FAS signaling. PTPs, such as KAP (also designated Cdi1), function to regulate the activity of proteins in the nuclei of cells. The second category of protein phosphatases dephosphorylate proteins on phosphoserine and phosphothreonine residues, whereas the third category of protein phosphatases exhibit dual specificities and can dephosphorylate proteins on phosphotyrosine and phosphoserine/phosphothreonine residues.

1540
Ad-PTP1C

Ready-to-use Protein tyrosine phosphatase, non-receptor type 6 Adenovirus. Ad-PTP1C, “Protein tyrosine phosphatase, non-receptor type 6”, HCP, HCPH, PTPN6, SHP-1, HPTP1C, PTP-1C, SHP-1L, SH-PTP1 adenovirus 1540

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
HCP; HCPH; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; PTP-1C; SHP1; SHP-1; SHP-1L; SH-PTP1; tyrosine-protein phosphatase non-receptor type 6
Description (eCommerce)
PTPN6/SHP-1 modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, SHP-1 induces UBE2V2 expression upon angiotensin II stimulation.SHP-1 plays a key role in hematopoiesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29350].
Description (Vector)
PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Gene ID
5777
Gene Name (eCommerce)
protein tyrosine phosphatase, non-receptor type 6
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 6
Gene Symbol
PTPN6
HGNC ID
HGNC:9658
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
Protein Name (eCommerce)
Tyrosine-protein phosphatase non-receptor type 6
RefSeq ID
NM_002831
RefSeq Synonyms
NM_080549, NM_080548, NM_002831, BC007667, BC002523,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cardiovascular,Cell Cycle,Cytokine Signaling,EGFR Signaling,EPO Signaling,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Phosphatase,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Translational Control,VEGF Signaling
Research Areas (Faceted)
cardiovascular,cancer,signal_transduction,cell_biology,immunology,cell_biology,cell_cycle,signal_transduction,immunology,signal_transduction,cell_biology,stem_cell_biology,signal_transduction,immunology,genetics,transcription_translation
Species
human
Target Sentence
PTPN6/SHP-1 modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, SHP-1 induces UBE2V2 expression upon angiotensin II stimulation.SHP-1 plays a key role in hematopoiesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P29350].
UniGene ID
Hs.63489
UniProt ID (eCommerce)
P29350

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.