Down syndrome critical region gene 1 Adenovirus

Name 
Ad-DSCR1
Cat No 
1539
Availability
Immediate
Categories
Adenovirus, Over-Expression

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

1539
Ad-DSCR1

Ready-to-use Down syndrome critical region gene 1 Adenovirus. Ad-DSCR1, Down syndrome critical region gene 1, CSP1, DSC1, RCN1, DSCR1, MCIP1, ADAPT78 adenovirus 1539

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
Description (Vector)
RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Gene ID
1827
Gene Name (Vector)
regulator of calcineurin 1
Gene Symbol
RCAN1
HGNC ID
HGNC:3040
ORF Size (aa)
594
RefSeq ID
NM_004414
RefSeq Synonyms
NM_203418, NM_203417, NM_004414, NM_001331016, NM_001285393, NM_001285392, NM_001285391, NM_001285389, BC002864,
Species
human
UniGene ID
Hs.282326

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.