Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Adenovirus

CVID10; DNA-binding factor KBF2; H2TF1; lymphocyte translocation chromosome 10 protein; LYT10; LYT-10; NFKB, p52/p100 subunit; NF-kB2; nuclear factor Kappa-B, subunit 2; nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); oncogene Lyt-10; p100; p49/p100; p52; transcription factor NFKB2

The NFKB2 gene encodes a 100 kDa protein that can undergo co-translational processing to also yield a 52 kDa protein. The 52 kDa protein is also known as NF-kappa B2/p52 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 100 kDa product is also known as p100 or I kappa B delta. P100/I kappa B delta has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. P100/I kappa B delta is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress.

NFKB2 encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. NFKB2 encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants.

4791

nuclear factor kappa B subunit 2

nuclear factor kappa B subunit 2

NFKB2

HGNC:7795

9606.0

2700

2700 bp

Nuclear factor NF-kappa-B p100 subunit

NM_002502

NM_002502, NM_001322935, NM_001322934, NM_001288724, NM_001261403, NM_001077494, NM_001077493, BC002844,

Cancer,Cytokine Signaling,DNA Damage/Repair,EGFR Signaling,Helicase Activity,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,NF-kB Signaling,RANKL-RANK Signaling,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TSLP Signaling,TWEAK Signaling,Viral Carcinogenesis

cancer,cell_biology,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction

human

The NFKB2 gene encodes a 100 kDa protein that can undergo co-translational processing to also yield a 52 kDa protein. The 52 kDa protein is also known as NF-kappa B2/p52 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 100 kDa product is also known as p100 or I kappa B delta. P100/I kappa B delta has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. P100/I kappa B delta is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress.

Hs.73090

Q00653