BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Adenovirus

Name 
Ad-BRCA-AP1
Cat No 
1521
Availability
Immediate
Categories
Adenovirus, Over-Expression

The breast cancer susceptibility gene, BRCA1, which maps to chromosome 17q is expressed in numerous tissues, including breast and ovary. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast and ovarian cancer. Mutations within the BRCA1 gene may account for at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. BRCA-AP1, also known as BAP1 (BRCA1 associated protein 1), localizes to the nucleus and interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway.

1521
Ad-BRCA-AP1

Ready-to-use BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Adenovirus. Ad-BRCA-AP1, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BAP1, HUCEP-6, HUCEP-13 adenovirus 1521

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; cerebral protein 6; cerebral protein-13; HUCEP-13; hucep-6; ubiquitin carboxyl-terminal hydrolase BAP1; UCHL2
Description (eCommerce)
BRCA1-associated protein 1 (BAP1) functions as a C-terminal ubiquitin hydrolase and may be involved in the transduction of signals in the BRCA1 pathway. BAP1 is also implicated to be a tumor suppressor as defects in BAP1 are found in non-small cell lung cancer cell lines.
Description (Vector)
BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
Gene ID
8314
Gene Name (eCommerce)
BRCA1 associated protein 1
Gene Name (Vector)
BRCA1 associated protein 1
Gene Symbol
BAP1
HGNC ID
HGNC:950
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2190
ORF Size (bp)
2190 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase BAP1
RefSeq ID
NM_004656
RefSeq Synonyms
NM_004656, BC001596,
Research Areas
Cancer,Cell Cycle,Histone Modification,Tumor Suppressors/Oncoproteins,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
BRCA1-associated protein 1 (BAP1) functions as a C-terminal ubiquitin hydrolase and may be involved in the transduction of signals in the BRCA1 pathway. BAP1 is also implicated to be a tumor suppressor as defects in BAP1 are found in non-small cell lung cancer cell lines.
UniGene ID
Hs.106674
UniProt ID (eCommerce)
Q92560

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.