Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 Adenovirus

Name 
Ad-NFATc3
Cat No 
1516
Availability
Immediate
Categories
Adenovirus, Over-Expression

The NFAT (nuclear factor of activated T cells) family of transcription factors include the cytoplasmic NFAT transcription factors (NFATc1, NFATc2, NFATc3, NFATc4 and NFATc5) and nuclear NFAT (NFATn). NFATc1 is present in uninduced cells and translocates to the nucleus upon calcium mobilization. NFATc3 is preferentially expressed in the thymus and may be involved in the regulation of gene expression in T cells and immature thymocytes. In general, NFATs are involved in the regulation of cytokine promoter function.

1516
Ad-NFATc3

Ready-to-use Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 Adenovirus. Ad-NFATc3, “Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3”, NFAT4, NFATX, NFATC3 adenovirus 1516

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
NFAT4; NF-AT4; NFATc3; NF-ATc3; NFATX; nuclear factor of activated T-cells c3 isoform IE-Xa; nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
Description (eCommerce)
Nuclear factor of activated T cells, cytoplasmic 1(NFATc3) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFATc3 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of IL-2.
Description (Vector)
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
4775
Gene Name (eCommerce)
nuclear factor of activated T cells 3
Gene Name (Vector)
nuclear factor of activated T-cells 3
Gene Symbol
NFATC3
HGNC ID
HGNC:7777
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3228
ORF Size (bp)
3228 bp
Protein Name (eCommerce)
Nuclear factor of activated T-cells, cytoplasmic 3
RefSeq ID
NM_004555
RefSeq Synonyms
NM_173165, NM_173163, NM_004555, BC001050,
Research Areas
Axon Guidance,B-cell Receptor Signaling,Cancer,Cardiac Development,Cardiology,Cardiovascular,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,MAPK Signaling,Neurobiology,NFAT Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Nuclear factor of activated T cells, cytoplasmic 1(NFATc3) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFATc3 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of IL-2.
UniGene ID
Hs.632209
UniProt ID (eCommerce)
Q12968

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.