FK506 binding protein 1A, 12kDa Adenovirus

Name 
Ad-FKBP12
Cat No 
1514
Availability
Immediate
Categories
Adenovirus, Over-Expression

The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Several related immunophilins, FKBP12, FKBP51 and FKBP52 are characterized as cytosolic FK506-binding proteins. Following ligand binding, they functionally inhibit the phosphatase activity of calcineurin. These related proteins have distinct molecular masses and differential expression patterns. FKBP12 and FKBP52 are both widely expressed and have molecular masses of 12 kDa and 52 kDa, respectively. FKBP51 is a 51 kDa protein that is predominantly expressed in T cells, where it blocks T cell activation.

1514
Ad-FKBP12

Ready-to-use FK506 binding protein 1A, 12kDa Adenovirus. Ad-FKBP12, “FK506 binding protein 1A, 12kDa”, FKBP1, PKC12, PKCI2, FKBP12, FKBP1A, PPIASE, FKBP-12, FKBP12C adenovirus 1514

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
Description (Vector)
FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Gene ID
2280
Gene Name (Vector)
FK506 binding protein 1A
Gene Symbol
FKBP1A
HGNC ID
HGNC:3711
ORF Size (aa)
438
RefSeq ID
NM_054014
RefSeq Synonyms
NM_054014, NM_001199786, NM_000801, BC119732, BC005147, BC001925,
Species
human
UniGene ID
Hs.700839

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.