Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) Adenovirus
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. The human sirtuins, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 is widely expressed and regulates p53 function through its deacetylation at lysine 382.
1512
Ad-SIRT5
Ready-to-use Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) Adenovirus. Ad-SIRT5, Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), SIRT5, SIR2L5 adenovirus 1512
Gene Reference Data
Alternate Names
SIR2L5
Description (Vector)
SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Gene ID
23408
Gene Name (Vector)
sirtuin 5
Gene Symbol
SIRT5
HGNC ID
HGNC:14933
ORF Size (aa)
933
RefSeq ID
NM_012241
RefSeq Synonyms
NM_031244, NM_012241, NM_001242827, NM_001193267, BC000126,
Species
human
UniGene ID
Hs.594133
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.