TNF receptor-associated factor 4 Adenovirus

Name 
Ad-TRAF4
Cat No 
1511
Availability
Immediate
Categories
Adenovirus, Over-Expression

TNF receptor-associated factors 1 and 2 (TRAF1 and TRAF2) are two related proteins that form a heterodimeric complex that associates with the cytoplasmic domain of the tumor necrosis factor (TNF) receptor type 2. A third member of this family, TRAF3 (also designated CD40bp or CRAF1), associates with the cytoplasmic domain of CD40. Three additional members of the TRAF/CRAF family of signaling intermediates include TRAF4 (also designated CART1), TRAF5 and TRAF6. TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK.

1511
Ad-TRAF4

Ready-to-use TNF receptor-associated factor 4 Adenovirus. Ad-TRAF4, TNF receptor-associated factor 4, CART1, MLN62, RNF83, TRAF4 adenovirus 1511

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CART1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF83; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
Description (eCommerce)
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF4 seems to mediate activation of NF-kappa-B and JNK and to be involved in apoptosis. TRAF4 may play a role in the development of respiratory tract. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUZ4].
Description (Vector)
TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
Gene ID
9618
Gene Name (eCommerce)
TNF receptor associated factor 4
Gene Name (Vector)
TNF receptor associated factor 4
Gene Symbol
TRAF4
HGNC ID
HGNC:12034
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1413
ORF Size (bp)
1413 bp
Protein Name (eCommerce)
TNF receptor-associated factor 4
RefSeq ID
NM_004295
RefSeq Synonyms
NM_004295, BC001769,
Research Areas
Apoptosis,Cancer,Cytoskeleton,JNK Signaling,Lung Cancer,Signal Transduction,TNF Signaling,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology
Species
human
Target Sentence
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF4 seems to mediate activation of NF-kappa-B and JNK and to be involved in apoptosis. TRAF4 may play a role in the development of respiratory tract. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUZ4].
UniGene ID
Hs.8375
UniProt ID (eCommerce)
Q9BUZ4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.