Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Adenovirus

Name 
Ad-Id-1
Cat No 
1507
Availability
Immediate
Categories
Adenovirus, Over-Expression

Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and bHLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Id1 inhibits DNA binding of E12 and Myo D and inhibits muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, which allows E12 and/or E47 to form heterodimers with Myo D and myogenin to activate myogenic differentiation. Expression of each of the Id proteins is strongly dependent on growth factor activation. A reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed re-entry of arrested cells into the cell cycle following growth factor stimulation.

1507
Ad-Id-1

Ready-to-use Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Adenovirus. Ad-Id-1, “Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein”, ID, ID1 adenovirus 1507

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
bHLHb24; ID
Description (Vector)
ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
3397
Gene Name (Vector)
inhibitor of DNA binding 1, HLH protein
Gene Symbol
ID1
HGNC ID
HGNC:5360
ORF Size (aa)
468
RefSeq ID
NM_002165
RefSeq Synonyms
NM_181353, NM_002165, BC012420, BC000613,
Species
human
UniGene ID
Hs.504609

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.