Superoxide dismutase 1, soluble Adenovirus
The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a 22 kDa homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. SOD-1 activity depends on the delivery of copper cofactors by Copper chaperone for SOD-1 (CCS). CCS prevents copper ions from binding to intracellular scavengers, thus securing copper for SOD-1.
1503
Ad-SOD1
Ready-to-use Superoxide dismutase 1, soluble Adenovirus. Ad-SOD1, “Superoxide dismutase 1, soluble “, ALS, SOD, ALS1, IPOA, SOD1 adenovirus 1503
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Gene Reference Data
Alternate Names
ALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; superoxide dismutase Cu-Zn; Superoxide dismutase 1; superoxide dismutase 1, soluble; superoxide dismutase, cystolic
Description (eCommerce)
Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].
Description (Vector)
SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Gene ID
6647
Gene Name (eCommerce)
superoxide dismutase 1
Gene Name (Vector)
superoxide dismutase 1, soluble
Gene Symbol
SOD1
HGNC ID
HGNC:11179
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
465
Protein Name (eCommerce)
Superoxide dismutase [Cu-Zn]
RefSeq ID
NM_000454
RefSeq Synonyms
NM_000454, BC001034,
Research Areas
Aging,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cancer,Cardiology,Cardiovascular,Cytoskeleton,DNA Damage/Repair,Huntington's Disease,IGF-1 Signaling,Immunology,Interleukin Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,neurobiology,cardiovascular,cell_biology,genetics,transcription_translation,neurobiology,signal_transduction,immunology,metabolism,cell_biology,neurobiology,developmental_biology,cell_biology,cell_cycle
Species
human
Target Sentence
Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].
UniGene ID
Hs.443914
UniProt ID (eCommerce)
P00441
Related Citations
- Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model. Sabyasachi Se, etc, (2015), Stem Cell Research & Therapy
- Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo. Shuvaev VV, etc, (2013), PLoS ONE
- Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. Ursula A, etc, (2011), FASEB Journal
- Catalase and Superoxide Dismutase Conjugated with Platelet-Endothelial Cell Adhesion Molecule Antibody Distinctly Alleviate Abnormal Endothelial Permeability Caused by Exogenous Reactive Oxygen Species and Vascular Endothelial Growth Factor. Han J, etc, (2011), Journal of Pharmacology
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.