Histone deacetylase 1 Adenovirus

Name 
Ad-HDAC1
Cat No 
1498
Availability
Immediate
Categories
Adenovirus, Over-Expression

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical process in transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the N-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility of transcription factors to DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Mammalian nuclear histone acetylases include GCN5, PCAF (p300/CBP-associated factor), HAT1, MOF, HBO, MOZ, MORF and TIP60.1.

1498
Ad-HDAC1

Ready-to-use Histone deacetylase 1 Adenovirus. Ad-HDAC1, Histone deacetylase 1, HD1,RPD3,HDAC1,RPD3L1 adenovirus 1498

$475.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
GON-10; HD1; histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
Description (eCommerce)
Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription.
Description (Vector)
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Gene ID
3065
Gene Name (eCommerce)
histone deacetylase 1
Gene Name (Vector)
histone deacetylase 1
Gene Symbol
HDAC1
HGNC ID
HGNC:4852
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
Histone deacetylase 1
RefSeq ID
NM_004964
RefSeq Synonyms
NM_004964, BC000301,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cell Cycle,Chromatin Remodeling,EGFR Signaling,Epigenetic Regulation of Gene Expression,Gene Expression,Hedgehog Signaling,Histone Modification,Host-Virus Interactions,Huntington's Disease,Immunology,Interleukin Signaling,Leukemia,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,TWEAK Signaling,Viral Carcinogenesis,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription.
UniGene ID
Hs.88556
UniProt ID (eCommerce)
Q13547

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.