Aurora kinase B Adenovirus

Name 
Ad-AURORA-2
Cat No 
1497
Availability
Immediate
Categories
Adenovirus, Over-Expression

Aurora related kinase-1 (ARK-1, STK15, STK6, Aurora2) and -2 (ARK-2, STK12, Aurora1) are centrosome-associated serine/threonine kinases that regulate centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. First characterized in human colorectal cancers, ARK-1 and -2 are closely related to Drosophila aurora kinases. ARK-1 protein has elevated expression in colon carcinoma lines (HT-29, SNU-C2B, COLO 205, SW480, 837 and 948) and accumulates during metaphase in HeLa cells. ARK-1 and -2 have unique genetic loci, suggesting that these two kinases, with oncogenic potential, play different roles in cell cycle progression.

1497
Ad-AURORA-2

Ready-to-use Aurora kinase B Adenovirus. Ad-AURORA-2, Aurora kinase B, AIK2,AIM1,ARK2,AURB,IPL1,STK5,AIM-1,AURKB,STK12 adenovirus 1497

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
AIK2; AIM1; AIM-1; ARK2; ARK-2; AurB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Description (eCommerce)
Aurora B is the central enzymatic unit of the chromosomal passenger complex (CPC). In the CPC, Aurora B is associated with the passenger proteins inner centromeric protein (INCENP), survivin, and borealin. Aurora B is a serine-threonine protein kinase essential for chromosome segregation and cytokinesis. Specific roles for Aurora B have been demonstrated in cohesin dissociation from centromeres as well as condensin I binding to chromatin.F112. Substrates of Aurora B kinase activity include desmin, septin 1, INCENP, RAC GTPase activating protein 1, and centromeric protein A.
Description (Vector)
AURKB encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromsomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9212
Gene Name (eCommerce)
aurora kinase B
Gene Name (Vector)
aurora kinase B
Gene Symbol
AURKB
HGNC ID
HGNC:11390
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1035
ORF Size (bp)
1035 bp
Protein Name (eCommerce)
Aurora kinase B
RefSeq ID
NM_004217
RefSeq Synonyms
NM_004217, NM_001313955, NM_001313954, NM_001313953, NM_001313952, NM_001313951, NM_001313950, NM_001284526, NM_001256834, BC080581, BC009751, BC000442,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,Histone Modification,Immunology,Kinase/Phosphatase,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,immunology,cell_biology
Species
human
Target Sentence
Aurora B is the central enzymatic unit of the chromosomal passenger complex (CPC). In the CPC, Aurora B is associated with the passenger proteins inner centromeric protein (INCENP), survivin, and borealin. Aurora B is a serine-threonine protein kinase essential for chromosome segregation and cytokinesis. Specific roles for Aurora B have been demonstrated in cohesin dissociation from centromeres as well as condensin I binding to chromatin.F112. Substrates of Aurora B kinase activity include desmin, septin 1, INCENP, RAC GTPase activating protein 1, and centromeric protein A.
UniGene ID
Hs.442658
UniProt ID (eCommerce)
Q96GD4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.