C-reactive protein, pentraxin-related Adenovirus
Inflammation results in a rapid increase in blood levels of acute phase proteins synthesized by hepatocytes in response to cytokines. Pentraxins, which include C reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. Human serum amyloid A (SAA) is also a major acute-phase protein and precursor to amyloid A protein (AA), which is the major constituent of the fibril deposits of reactive amyloidosis.
1495
Ad-CRP
Ready-to-use C-reactive protein, pentraxin-related Adenovirus. Ad-CRP, “C-reactive protein, pentraxin-related”, CRP, PTX1 adenovirus 1495
Gene Reference Data
Alternate Names
C-reactive protein; C-reactive protein, pentraxin-related; pentraxin 1; PTX1
Description (eCommerce)
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 infection. [provided by RefSeq, Aug 2020]
Description (Vector)
CRP belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
Gene ID
1401
Gene Name (eCommerce)
C-reactive protein
Gene Name (Vector)
C-reactive protein, pentraxin-related
Gene Symbol
CRP
HGNC ID
HGNC:2367
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
675
ORF Size (bp)
675 bp
Protein Name (eCommerce)
C-reactive protein
RefSeq ID
NM_000567
RefSeq Synonyms
NM_001329058, NM_001329057, NM_000567, BC125135, BC070257,
Research Areas
Hypoxia,Immunology,Innate Immunity,Interleukin Signaling,Leptin Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 infection. [provided by RefSeq, Aug 2020]
UniGene ID
Hs.709456
UniProt ID (eCommerce)
P02741
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.