Toll-like receptor 4 Adenovirus

Name 
Ad-TLR4
Cat No 
1486
Availability
Immediate
Categories
Adenovirus, Over-Expression

Toll-like receptors (TLR) are fundamental for pathogen recognition and initiation of the innate immune response. TLRs recognize pathogen contours and mediate the production of cytokines necessary for immunity toward the pathogen. There is a high level of conservation in TLRs, both structurally and functionally, from Drosophila to humans. The TLR family of proteins is characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. Another TLR protein, RP105, is predominately expressed on mature B-cells and has a striking similarity to TLR4.

1486
Ad-TLR4

Ready-to-use Toll-like receptor 4 Adenovirus. Ad-TLR4, Toll-like receptor 4, TLR4, Lps, Ly87, Ran/M1, Rasl2-8 adenovirus 1486

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
Lps; Ly87; Ran/M1; Rasl2-8
Description (Vector)
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
Gene ID
21898
Gene Name (Vector)
toll-like receptor 4
Gene Symbol
Tlr4
ORF Size (aa)
2508
ORF Size (bp)
2508 bp
RefSeq ID
NM_021297
RefSeq Synonyms
NM_021297, BC029856,
Species
mouse
UniGene ID
Mm.38049

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.