Homeodomain interacting protein kinase 2 Adenovirus
The homeodomain-interacting protein kinase (HIPK) family includes three members, HIPK1, HIPK2, and HIPK3. Each family member contains a conserved protein kinase domain as well as a separate domain, which interacts with homeoproteins. HIPK2 appears to act as a corepressor of homeodomain transcription factors, such as NK-3. Also, HIPK2 is regulated by ubiquitin-like modification via the covalent binding of SUMO-1. Subsequently, it is directed to nuclear bodies in vitro.
1484
Ad-HIPK2
Ready-to-use Homeodomain interacting protein kinase 2 Adenovirus. Ad-HIPK2, Homeodomain interacting protein kinase 2, HIPK2, STANK adenovirus 1484
Gene Reference Data
Alternate Names
1110014O20Rik; B230339E18Rik; Stank
Description (Vector)
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phoyphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Gene ID
15258
Gene Name (Vector)
homeodomain interacting protein kinase 2
Gene Symbol
Hipk2
ORF Size (aa)
3510
ORF Size (bp)
3510 bp
RefSeq ID
NM_010433
RefSeq Synonyms
NM_010433, NM_001294144, NM_001294143, NM_001136065, BC031904,
Species
mouse
UniGene ID
Mm.391962
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.