Aurora kinase A Adenovirus

Name 
Ad-Aurora-A
Cat No 
1474
Availability
Immediate
Categories
Adenovirus, Over-Expression

Aurora related kinase-1 (ARK-1, STK15, STK6, Aurora2) and -2 (ARK-2, STK12, Aurora1) are centrosome-associated serine/threonine kinases that regulate centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. First characterized in human colorectal cancers, ARK-1 and -2 are closely related to Drosophila aurora kinases. ARK-1 protein has elevated expression in colon carcinoma lines (HT-29, SNU-C2B, COLO 205, SW480, 837 and 948) and accumulates during metaphase in HeLa cells. ARK-1 and -2 have unique genetic loci, suggesting that these two kinases, with oncogenic potential, play different roles in cell cycle progression.

1474
Ad-Aurora-A

Ready-to-use Aurora kinase A Adenovirus. Ad-Aurora-A, Aurora kinase A, IAK, Ark1, Ayk1, Stk6, AIRK1, Aurora-A adenovirus 1474

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
AIRK1; ARK-1; Ark1; AU019385; Aurora-A; AW539821; Ayk1; IAK; IAK1; Stk6
Description (Vector)
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Gene ID
20878
Gene Name (Vector)
aurora kinase A
Gene Symbol
Aurka
ORF Size (aa)
1188
ORF Size (bp)
1188 bp
RefSeq ID
NM_011497
RefSeq Synonyms
NM_011497, NM_001291185, BC014711, BC005425,
Species
mouse
UniGene ID
Mm.249363

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.