Amyloid beta (A4) precursor protein Adenovirus
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
1472
Ad-Ab
Ready-to-use Amyloid beta (A4) precursor protein Adenovirus. Ad-Ab, Amyloid beta (A4) precursor protein, AAA,AD1,APP,PN2,ABPP,APPI,BETA,CVAP,ABETA,PREA4,AMYLOID adenovirus 1472
Gene Reference Data
Alternate Names
AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Description (Vector)
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Gene ID
351
Gene Name (Vector)
amyloid beta precursor protein
Gene Symbol
APP
HGNC ID
HGNC:620
ORF Size (aa)
2256
ORF Size (bp)
2256 bp
RefSeq ID
NM_000484
RefSeq Synonyms
NM_201414, NM_201413, NM_001204303, NM_001204302, NM_001204301, NM_001136131, NM_001136130, NM_001136129, NM_001136016, NM_000484, BC065529, BC004369,
Species
human
UniGene ID
Hs.434980
Related Citations
- APP-dependent alteration of GSK3ß activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. Stefania Trazzi, etc, (2014), Neurobiology of Disease
- The Amyloid Precursor Protein (APP) Triplicated Gene Impairs Neuronal Precursor Differentiation and Neurite Development through Two Different Domains in the Ts65Dn Mouse Model for Down Syndrome. Trazzi S, etc, (2013), JBC
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.