v-myb myeloblastosis viral oncogene homolog (avian) Adenovirus

Name 
Ad-c-Myb
Cat No 
1469
Availability
Immediate
Categories
Adenovirus, Over-Expression

The Myb family of transcription factors regulate differentiation and cellular growth through binding to promoters with the consensus sequence 5′-AAC(G/T)G-3′ and transactivating gene expression. The proto-oncogene c-Myb is the cellular homolog of the leukemogenic avian retroviral protein v-Myc, and c-Myc is expressed predominantly in immature and rapidly dividing hematopoietic cells. Additional members of the family include B-Myb, a 110 kDa protein that is expressed in a wide variety of proliferating cells at the G1 to S phase transition, and A-Myb, which is expressed in reproductive tissues, some neural cells and a subset of normal and neoplastic B lymphocytes. Transactivation properties of B-Myb are apparently dependent upon the protein’s hyperphosphorylation at several C-terminal residues, including Thr 447, Thr 490, Thr 497 and Ser 581. Dmp1 is related to the Myb family and also functions as a transcriptional activator. Dmp1 contains three tandem Myb repeats and is a putative substrate for cyclin D-dependent kinase.

1469
Ad-c-Myb

Ready-to-use v-myb myeloblastosis viral oncogene homolog (avian) Adenovirus. Ad-c-Myb, v-myb myeloblastosis viral oncogene homolog (avian), EFG,MYB,C-MYB,C-MYB_CDS adenovirus 1469

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
Cmyb; c-myb; c-myb_CDS; efg; oncogene AMV; proto-oncogene c-Myb; transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog
Description (eCommerce)
c-Myb is a member of the MYB family of transcription factors. C-Myb contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. C-myb plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 3093)].
Description (Vector)
MYB encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
Gene ID
4602
Gene Name (eCommerce)
MYB proto-oncogene, transcription factor
Gene Name (Vector)
MYB proto-oncogene, transcription factor
Gene Symbol
MYB
HGNC ID
HGNC:7545
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1923
ORF Size (bp)
1923 bp
Protein Name (eCommerce)
Transcriptional activator Myb
RefSeq ID
NM_005375
RefSeq Synonyms
NM_005375, NM_001161660, NM_001161659, NM_001161658, NM_001161657, NM_001161656, NM_001130173, NM_001130172, BC064955,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,Neurobiology,Neurodevelopment,PI3K/Akt Signaling,Prolactin Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,immunology,signal_transduction,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation
Species
human
Target Sentence
c-Myb is a member of the MYB family of transcription factors. C-Myb contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. C-myb plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis [taken from NCBI Entrez Gene (Gene ID: 3093)].
UniGene ID
Hs.654446
UniProt ID (eCommerce)
P10242

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.