SMAD, mothers against DPP homolog 3 (Drosophila) Adenovirus
Mammalian homologs of the Drosophila Mad gene include Smad1 (also designated Madr1 or JV4-1), Smad2 (also designated Madr2 or JV18-1), Smad3, Smad4 (also designated DPC4), Smad5, Smad6, Smad7 and Smad8 (also designated Smad9). Smad1 and Smad5 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGFb and activin-mediated growth modulation. Smad4 is required for all of the above activities and necessitates FAST-1 for DNA binding. Smad6 and Smad7 regulate the response to activin/ TGFb signaling by interfering with TGFb-mediated phosphorylation of other Smad family members.
1460
Ad-SMAD3
Ready-to-use SMAD, mothers against DPP homolog 3 (Drosophila) Adenovirus. Ad-SMAD3, “SMAD, mothers against DPP homolog 3 (Drosophila)”, SMAD,MADH3,SMAD3,JV15-2,HSPC193,HST17436,MGC60396,DKFZP586N0721 adenovirus 1460
Gene Reference Data
Alternate Names
hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; mad3; MADH3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD 3; SMAD family member 3; SMAD, mothers against DPP homolog 3; Smad3
Description (eCommerce)
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 4088)].
Description (Vector)
SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
Gene ID
4088
Gene Name (eCommerce)
SMAD family member 3
Gene Name (Vector)
SMAD family member 3
Gene Symbol
SMAD3
HGNC ID
HGNC:6769
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
Protein Name (eCommerce)
Mothers against decapentaplegic homolog 3
RefSeq ID
NM_005902
RefSeq Synonyms
NM_005902, NM_001145104, NM_001145103, NM_001145102, BC050743, BC000414,
Research Areas
Apoptosis,Autophagy,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,EGFR Signaling,Gene Expression,Hippo Signaling,Host-Virus Interactions,Hypoxia,Immunology,Leukemia,Prostate Cancer,RNA Processing,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 4088)].
UniGene ID
Hs.714621
UniProt ID (eCommerce)
P84022
Related Citations
- Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. S Chakraborty, etc, (2018), British Journal of Cancer
- A negative feedback control of TGF-beta signaling by GSK3-mediated Smad3 linker phosphorylation at Ser204. Millet C, etc, (2009), J Biol Chem
- A Novel Role of Transforming Growth Factor ß1 in Transcriptional Repression of Human Cholesterol 7a-Hydroxylase Gene. Lia T. etc, (2007), Gastroenterology
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.