Lymphoid enhancer-binding factor 1 Adenovirus

Name 
Ad-LEF1
Cat No 
1457
Availability
Immediate
Categories
Adenovirus, Over-Expression

T-cell factor (TCF-1) and lymphoid enhancer-binding factor (for LEF-1, also designated TCF-1(alpha)) compose a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. LEF-1, TCF-1, and two other family members, TCF-3 and TCF-4, directly bind to cytosolic beta-catenin and facilitate its translocation to the nucleus, where these complexes induce expression of Wnt target genes.

1457
Ad-LEF1

Ready-to-use Lymphoid enhancer-binding factor 1 Adenovirus. Ad-LEF1, Lymphoid enhancer-binding factor 1, LEF1,TCF1ALPHA, TCF1 adenovirus 1457

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
LEF-1; lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF10; TCF1ALPHA; TCF1-alpha; TCF7L3
Description (eCommerce)
Lymphoid enhancer-binding factor 1 (LEF1) is transcription factor involved in the Wnt signaling pathway. In cooperation with beta-catenin it activates transcription of target genes critical to development.
Description (Vector)
LEF1 encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. LEF1 has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
Gene ID
51176
Gene Name (eCommerce)
lymphoid enhancer binding factor 1
Gene Name (Vector)
lymphoid enhancer binding factor 1
Gene Symbol
LEF1
HGNC ID
HGNC:6551
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
Protein Name (eCommerce)
Lymphoid enhancer-binding factor 1
RefSeq ID
NM_016269
RefSeq Synonyms
NM_016269, NM_001166119, NM_001130714, NM_001130713, BC050632, BC040559,
Research Areas
Angiogenesis,Apoptosis,Brain Development,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Colorectal Cancer,Estrogen Signaling,Gene Expression,Hippo Signaling,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,Leukemia,Neurobiology,Neurodevelopment,Neurogenesis,Notch Signaling,Nuclear Receptor Coactivators,Prostate Cancer,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Lymphoid enhancer-binding factor 1 (LEF1) is transcription factor involved in the Wnt signaling pathway. In cooperation with beta-catenin it activates transcription of target genes critical to development.
UniGene ID
Hs.555947
UniProt ID (eCommerce)
Q9UJU2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.