Alternate Names
CVID12; DNA-binding factor KBF1; EBP-1; KBF1; NFkappaB; NF-kappaB; NF-kappa-B1; NF-kappabeta; NF-kB1; NFKB-p105; NFKB-p50; nuclear factor kappa-B DNA binding subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
Description (eCommerce)
The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress.
Description (Vector)
NFKB1 encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4790
Gene Name (eCommerce)
nuclear factor kappa B subunit 1
Gene Name (Vector)
nuclear factor kappa B subunit 1
Gene Symbol
NFKB1
HGNC ID
HGNC:7794
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2910
ORF Size (bp)
2910 bp
Protein Name (eCommerce)
Nuclear factor NF-kappa-B p105 subunit
RefSeq ID
NM_003998
RefSeq Synonyms
NM_003998, NM_001319226, NM_001165412, BC051765,
Research Areas
Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,Cytokine Signaling,DNA Damage/Repair,EGFR Signaling,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,Helicase Activity,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,Mitochondrion,Neurobiology,Neurodevelopment,NF-kB Signaling,NGF Signaling,Notch Signaling,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,TSLP Signaling,TWEAK Signaling,Viral Carcinogenesis,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress.
UniGene ID
Hs.654408
UniProt ID (eCommerce)
P19838