MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) Adenovirus

Name 
Ad-MEF2D
Cat No 
1448
Availability
Immediate
Categories
Adenovirus, Over-Expression

Differentiation of myogenic cells is regulated by multiple positive and negative regulators. One well-characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5, Myf-6 (also designated MRF-4 or herculin) and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, ITF2 and HEB. The E2A gene encodes at lest two different proteins, E12 and E47, as a result of alternative splicing. The myocyte enhancing factor-2 (MEF-2) family of transcription factors includes four splice variants A, B, C and D which encode muscle-specific DNA binding proteins that recognize an A/T rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes.

1448
Ad-MEF2D

Ready-to-use MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) Adenovirus. Ad-MEF2D, “MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)”, MEF2D adenovirus 1448

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
MADS box transcription enhancer factor 2, polypeptide D; myocyte-specific enhancer factor 2D
Description (eCommerce)
Myocyte-specific enhancer factor 2D (MEF2D) is a transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific, growth-factor and stress-induced genes. MEF2D mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14814].
Gene ID
4209
Gene Name (eCommerce)
myocyte enhancer factor 2D
Gene Name (Vector)
myocyte enhancer factor 2D
Gene Symbol
MEF2D
HGNC ID
HGNC:6997
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1545
ORF Size (bp)
1545 bp
Protein Name (eCommerce)
Myocyte-specific enhancer factor 2D
RefSeq ID
NM_005920
RefSeq Synonyms
NM_005920, NM_001271629, BC054520, BC040949,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cardiac Development,Cardiology,Cardiovascular,Immunology,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,NFAT Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Myocyte-specific enhancer factor 2D (MEF2D) is a transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific, growth-factor and stress-induced genes. MEF2D mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14814].
UniGene ID
Hs.314327
UniProt ID (eCommerce)
Q14814

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.