Leptin (obesity homolog, mouse) Adenovirus

Name 
Ad-LEPTIN
Cat No 
1441
Availability
Immediate
Categories
Adenovirus, Over-Expression

This gene is similar to the mouse obesity gene (ob). The protein encoded by this gene is secreted by white adipocytes. In the mouse study, mutations in this gene are linked to severe and morbid obesity. The recessive obesity mutation, Ob, identified in 1950, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. It has been postulated that the Ob gene product may represent a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. Ob encodes a 4.5 kb adipose tissue-specific mRNA with a highly conserved 167 amino acid open reading frame. The Ob gene product has been identified as a 16 kDa secreted protein, designated leptin, that is apparently produced only in adipose tissue.

1441
Ad-LEPTIN

Ready-to-use Leptin (obesity homolog, mouse) Adenovirus. Ad-LEPTIN, “Leptin (obesity homolog, mouse)”, OB,LEP,OBS adenovirus 1441

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
LEPD; OB; OBS
Description (Vector)
LEP encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. LEP has also been linked to type 2 diabetes mellitus development.
Gene ID
3952
Gene Name (Vector)
leptin
Gene Symbol
LEP
HGNC ID
HGNC:6553
ORF Size (aa)
504
RefSeq ID
NM_000230
RefSeq Synonyms
NM_000230, BC069527, BC069452, BC069323, BC060830,
Species
human
UniGene ID
Hs.194236

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.