Interleukin-1 receptor-associated kinase 3 Adenovirus

Name 
Ad-IRAK3
Cat No 
1439
Availability
Immediate
Categories
Adenovirus, Over-Expression

Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL-1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. 100kDa IRAK-1 is implicated as an upstream mediator of NFkB activation. IRAK-2 is a proximal mediator of IL-1, a component of the IL-1R signaling complex and is required for IL-1R-induced NF?B activation. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells.

1439
Ad-IRAK3

Ready-to-use Interleukin-1 receptor-associated kinase 3 Adenovirus. Ad-IRAK3, Interleukin-1 receptor-associated kinase 3, IRAK3, IRAK-M adenovirus 1439

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ASRT5; IRAKM
Description (Vector)
IRAK3 encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Gene ID
11213
Gene Name (Vector)
interleukin 1 receptor associated kinase 3
Gene Symbol
IRAK3
HGNC ID
HGNC:17020
ORF Size (aa)
1791
ORF Size (bp)
1791 bp
RefSeq ID
NM_007199
RefSeq Synonyms
NM_007199, NM_001142523, BC069388, BC057800,
Species
human
UniGene ID
Hs.369265

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.