Histone deacetylase 4 Adenovirus
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical process in transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the N-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility of transcription factors to DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Mammalian nuclear histone acetylases include GCN5, PCAF (p300/CBP-associated factor), HAT1, MOF, HBO, MOZ, MORF and TIP60.1.
1435
Ad-HDAC4
Ready-to-use Histone deacetylase 4 Adenovirus. Ad-HDAC4, Histone deacetylase 4, HD4,HDAC4,HDACA,HA6116,HDAC-A,KIAA0288 adenovirus 1435
Gene Reference Data
Alternate Names
AHO3; BDMR; HA6116; HD4; HDAC-4; HDACA; HDAC-A; histone deacetylase 4; histone deacetylase A
Description (eCommerce)
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P56524].
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Gene ID
9759
Gene Name (eCommerce)
histone deacetylase 4
Gene Name (Vector)
histone deacetylase 4
Gene Symbol
HDAC4
HGNC ID
HGNC:14063
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2919
ORF Size (bp)
2919 bp
Protein Name (eCommerce)
Histone deacetylase 4
RefSeq ID
NM_006037
RefSeq Synonyms
NM_006037, BC039904,
Research Areas
Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,genetics,signal_transduction,cardiovascular,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,immunology,signal_transduction,neurobiology,developmental_biology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,infectious_disease
Species
human
Target Sentence
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P56524].
UniGene ID
Hs.688314
UniProt ID (eCommerce)
P56524
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.