Early growth response 2 (Krox-20 homolog, Drosophila) Adenovirus
Several immediate early response genes are transiently activated in serum- or growth factor-stimulated cells. The early growth response genes encode nuclear proteins Egr-1 (NGFI-A), Egr-2 (Krox20), Egr-3 and Egr-4 (NGFI-C), which contain zinc finger DNA-binding domains closely resembling those of the transcription factor Sp1. The Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. Wilms¬ø tumor nuclear protein (WT) is an anti-oncogene structurally related to the Egr family.
1426
Ad-EGR2
Ready-to-use Early growth response 2 (Krox-20 homolog, Drosophila) Adenovirus. Ad-EGR2, “Early growth response 2 (Krox-20 homolog, Drosophila)”, EGR2,CMT1D,CMT4E,KROX20, EGR-2 adenovirus 1426
Gene Reference Data
Alternate Names
AT591; CMT1D; CMT4E; KROX20
Description (Vector)
EGR2 is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
Gene ID
1959
Gene Name (Vector)
early growth response 2
Gene Symbol
EGR2
HGNC ID
HGNC:3239
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
RefSeq ID
NM_000399
RefSeq Synonyms
NM_001321037, NM_001136179, NM_001136178, NM_001136177, NM_000399, BC035625,
Species
human
UniGene ID
Hs.1395
Related Citations
- Epidermal Growth Factor Receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing Early Growth Response Protein (Egr2) expression. Chandra, A. etc, (2013), JBC
- Novel Pro-Survival Functions Of The Kruppel-Like Transcription Factor Egr2 In Promotion Of Macrophage Colony-Stimulating Factor-Mediated Osteoclast Survival Downstream Of The Mek/Erk Pathway. Bradley, E., etc., (2008), J Biol Chem
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.