Platelet-derived growth factor receptor, beta polypeptide Adenovirus
The platelet derived growth factor receptor (PDGFR) family comprises PDGFR-(alpha) and PDGFR-(beta), which are structurally related and endowed with protein tyrosine kinase domains. These receptors bind the three PDGF ligand isoforms with different affinities. PDGFR-(alpha) can bind to both A and B subunits of PDGF, while PDGFR-(beta) can only bind the B subunit. Chromosomal translocation of the PDGFR-beta gene is linked with chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.
1420
Ad-PDGF-R(beta)
Ready-to-use Platelet-derived growth factor receptor, beta polypeptide Adenovirus. Ad-PDGF-R(beta), “Platelet-derived growth factor receptor, beta polypeptide”, JTK12,PDGFR,CD140B,PDGFR1,PDGFRB,PDGF-R-BETA adenovirus 1420
Gene Reference Data
Alternate Names
Activated tyrosine kinase PDGFRB; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD antigen CD140b; CD140 antigen-like family member B; CD140B; IBGC4; IMF1; JTK12; KOGS; NDEL1-PDGFRB; PDGFR; PDGFR1; PDGFR-1; PDGF-R-beta; PDGFR-beta; PENTT; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
Description (eCommerce)
Platelet derived growth factor receptor beta is a cell surface tyrosine kinase receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB. These growth factors are members of the platelet-derived growth factor family and are mitogens for cells of mesenchymal origin. PDGFR beta is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. [taken from NCBI Entrez Gene (Gene ID: 5159)].
Description (Vector)
PDGFRB encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Gene ID
5159
Gene Name (eCommerce)
platelet derived growth factor receptor beta
Gene Name (Vector)
platelet derived growth factor receptor beta
Gene Symbol
PDGFRB
HGNC ID
HGNC:8804
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3321
ORF Size (bp)
3321 bp
Protein Name (eCommerce)
Platelet-derived growth factor receptor beta
RefSeq ID
NM_002609
RefSeq Synonyms
NM_002609, BC032224,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Lysosome,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Platelet derived growth factor receptor beta is a cell surface tyrosine kinase receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB. These growth factors are members of the platelet-derived growth factor family and are mitogens for cells of mesenchymal origin. PDGFR beta is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. [taken from NCBI Entrez Gene (Gene ID: 5159)].
UniGene ID
Hs.509067
UniProt ID (eCommerce)
P09619
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.