Signal transducer and activator of transcription 5A Adenovirus

Name 
Ad-STAT5
Cat No 
1416
Availability
Immediate
Categories
Adenovirus, Over-Expression

Stats (signal transducers and activators of transcription) are tyrosine phosphorylated transcription factors activated by JAK family kinases. Various ligands, including interferons and growth factors, induce activation of the JAK kinases, which induce Stat activation. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer that is part of the ISGF-3 transcription factor complex. Stat3(alpha) is activated by EGF and IL-6. Stat3(alpha) is activated by EGF. Highest expression of Stat4 is observed in the testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 can be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Stat-1 and Stat-3 bind the serum-inducible element (SIE) and GAS/ISRE elements are also known to be STAT-binding sites.

1416
Ad-STAT5

Ready-to-use Signal transducer and activator of transcription 5A Adenovirus. Ad-STAT5, Signal transducer and activator of transcription 5A, MGF,STAT5,STAT5A adenovirus 1416

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; MGF; signal transducer and activator of transcription 5A; STAT5
Description (eCommerce)
Signal transducer and activator of transcription 5a (STAT5a) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones [taken from NCBI Entrez Gene (Gene ID: 6776)].
Description (Vector)
STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
Gene ID
6776
Gene Name (eCommerce)
signal transducer and activator of transcription 5A
Gene Name (Vector)
signal transducer and activator of transcription 5A
Gene Symbol
STAT5A
HGNC ID
HGNC:11366
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2385
ORF Size (bp)
2385 bp
Protein Name (eCommerce)
Signal transducer and activator of transcription 5A
RefSeq ID
NM_003152
RefSeq Synonyms
NM_003152, NM_001288720, NM_001288719, NM_001288718, BC027036,
Research Areas
Apoptosis,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,CD40 Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,EPO Signaling,FGF Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leukemia,Metabolism/Metabolic Process,Neurobiology,PDGF Signaling,Prolactin Signaling,RAC1 Signaling,SCF-KIT Signaling,Signal Transduction,TNF Signaling,TPO Signaling,Transcription Factor/Regulator,TSLP Signaling,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Signal transducer and activator of transcription 5a (STAT5a) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones [taken from NCBI Entrez Gene (Gene ID: 6776)].
UniGene ID
Hs.437058
UniProt ID (eCommerce)
P42229

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.