Fc fragment of IgG, low affinity IIb, receptor (CD32) Adenovirus

Name 
Ad-CD32
Cat No 
1414
Availability
Immediate
Categories
Adenovirus, Over-Expression

CD32 (also designated Fc gamma RII) is a 40 kDa low affinity receptor for the Fc fragment of aggregated IgG. CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells. CD32 is a cell surface marker that exists as several isoforms, which are produced by alternative splicing. The cytoplasmic portion of FcRIIA and FcRIIC contains an activatory ITAM motif whereas FcRIIB contains an inhibitory ITIM motif. Differential splicing of FcRIIB gene yields two isoforms FcRIIB1and FcRIIB2. All forms are present on monocytes, placental trophoblasts and endothelial cells. Neutrophils express FcRIIA and C. FcRIIB is expressed by B lymphocytes and mast cells. In platelets and megakaryocytes, CD32 is noncovalently associates with a member of the immunoglobin superfamily glycoprotein VI (GPVI), which is a collagen receptor that plays a critical role in collagen-induced platelet aggregation. GPVI exists as 55 kDa protein in megakaryocytes and a 58 kDa protein in platelets.

1414
Ad-CD32

Ready-to-use Fc fragment of IgG, low affinity IIb, receptor (CD32) Adenovirus. Ad-CD32, “Fc fragment of IgG, low affinity IIb, receptor (CD32)”, CD32,FCG2,FCGR2,IGFR2,FCGR2B adenovirus 1414

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
CD32; CD32B; FCG2; FCGR2; IGFR2
Description (Vector)
FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
2213
Gene Name (Vector)
Fc fragment of IgG receptor IIb
Gene Symbol
FCGR2B
HGNC ID
HGNC:3618
ORF Size (aa)
876
ORF Size (bp)
876 bp
RefSeq ID
NM_004001
RefSeq Synonyms
NM_004001, NM_001190828, NM_001002275, NM_001002274, NM_001002273, BC148273, BC146678, BC141826, BC031992,
Species
human
UniGene ID
Hs.654395

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.