B-cell CLL/lymphoma 2 Adenovirus
Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis). Various homodimers and heterodimers formed by proteins in this family either promote or inhibit apoptosis. Pro-apoptotic members of this family include Bax, Bcl-xS, Bad, Bak, NBK (Bik), BID, Hrk, Bok, Bim, NOXA, Diva and Bmf. Apoptotic inhibitors include Bcl-2, Bcl-xL, Bcl-x(beta), Bcl-x(gamma), Bcl-w, Mcl-1, Bag-1, A1 (Bfl-1), BAR and BI-1 (TEGT). Bok, or Bcl-2 related ovarian killer, induces apoptosis in cells, but is suppressed by anti-apoptotic Bcl-2 family proteins. BECN1 plays a significant role in autophagy. PUMA gene encodes two BH3 domain-containing proteins PUMA(alpha) and PUMA(beta), which have similar binding activities to Bcl-2, localize to the mitochondria to induce cytochrome c release and activate the rapid induction of programmed cell death.
1412
Ad-BCL2
Ready-to-use B-cell CLL/lymphoma 2 Adenovirus. Ad-BCL2, B-cell CLL/lymphoma 2, Bcl2 adenovirus 1412
Gene Reference Data
Alternate Names
apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50
Description (eCommerce)
B-cell CLL/lymphoma 2 (Bcl-2) is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl-2, such as in the case of translocation of Bcl-2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma [taken from NCBI Entrez Gene (Gene ID: 596)].
Description (Vector)
BCL2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Gene ID
596
Gene Name (eCommerce)
BCL2, apoptosis regulator
Gene Name (Vector)
B-cell CLL/lymphoma 2
Gene Symbol
BCL2
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
720
ORF Size (bp)
720 bp
Protein Name (eCommerce)
Apoptosis regulator Bcl-2
RefSeq ID
NM_000633
RefSeq Synonyms
NM_000657, NM_000633, BC027258,
Research Areas
Aging,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Autophagy,B-cell Receptor Signaling,Breast Cancer,Cancer,CD95/FAS Signaling,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,EGFR Signaling,EPO Signaling,Estrogen Signaling,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,Immunology,Innate Immunity,Interleukin Signaling,Kinase/Phosphatase,Lung Cancer,MicroRNAs in Cancer,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,NFAT Signaling,NF-kB Signaling,p53 Signaling,Parkinson's Disease,PI3K/Akt Signaling,Prostate Cancer,Response to Virus,SCF-KIT Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
B-cell CLL/lymphoma 2 (Bcl-2) is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl-2, such as in the case of translocation of Bcl-2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma [taken from NCBI Entrez Gene (Gene ID: 596)].
UniGene ID
Hs.150749
UniProt ID (eCommerce)
P10415
Related Citations
- Bcl-2 overexpression improves survival and efficacy of neural stem cell-mediated enzyme prodrug therapy. Mooney R, etc, (2018), Stem Cells
- Neuroserpin Attenuates H2O2-Induced Oxidative Stress in Hippocampal Neurons via AKT and BCL-2 Signaling Pathways. Cheng Y, etc, (2016), Journal of Molecular Neuroscience
- Adenoviral particles for Bcl-2 and DN-Caspase-9 used for the experiments were obtained from Vector BioLabs. Kochuparambil, ST, etc, (2012), BMC Cancer
- PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. Chi-Bun Chan, (2010), The Embo Journal
- WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death. Balachandar Venkatesan, (2010), Cellular Signalling
- Transcription Factor Gata4 Inhibits Doxorubicin-Induced Autophagy And Cardiomyocyte Death. Kobayashi, S. etc, (2010), J. Biol. Chem
- Hypersensitivity Of Ahr-Deficient Mice To Lps-Induced Septic Shock. Sekine H etc, (2009), Molecular and Cellular Biology
- The Ring Domain Of Ciap1 Mediates The Degradation Of Ring-Bearing Inhibitor Of Apoptosis Proteins By Distinct Pathways. Cheung HH, etc, (2008), Mol Biol Cell
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.