Caspase recruitment domain family, member 4 Adenovirus

Name 
Ad-NOD1
Cat No 
1408
Availability
Immediate
Categories
Adenovirus, Over-Expression

The mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), Nod1 (CARD4) and Nod2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker’s A box (P-loop) and B box (Mg2+-binding site). Nod1 contains a putative regulatory domain and multiple leucine-rich repeats. Nod1 is a member of a growing family of intracellular proteins that share structural homology to the apoptosis regulator Apaf-1. Nod2 comprises two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. Mutations in Nod2 confer susceptibility to Crohn disease, a chronic inflammatory bowel disorder.

1408
Ad-NOD1

Ready-to-use Caspase recruitment domain family, member 4 Adenovirus. Ad-NOD1, “Caspase recruitment domain family, member 4”, NOD1,CARD4 adenovirus 1408

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CARD4; CLR7.1; NLRC1
Description (Vector)
NOD1 encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.
Gene ID
10392
Gene Name (Vector)
nucleotide binding oligomerization domain containing 1
Gene Symbol
NOD1
HGNC ID
HGNC:16390
ORF Size (aa)
2862
ORF Size (bp)
2862 bp
RefSeq ID
NM_006092
RefSeq Synonyms
NM_006092, BC040339,
Species
human
UniGene ID
Hs.405153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.