Protein phosphatase 1A (formerly 2C), alpha isoform Adenovirus

Name 
Ad-PP1A
Cat No 
1405
Availability
Immediate
Categories
Adenovirus, Over-Expression

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis.

1405
Ad-PP1A

Ready-to-use Protein phosphatase 1A (formerly 2C), alpha isoform Adenovirus. Ad-PP1A, “Protein phosphatase 1A (formerly 2C), alpha isoform”, PPM1A, PP2CA, MGC9201, PP2C-ALPHA adenovirus 1405

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
PP2C-ALPHA; PP2CA; PP2Calpha
Description (Vector)
PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene ID
5494
Gene Name (Vector)
protein phosphatase, Mg2+/Mn2+ dependent 1A
Gene Symbol
PPM1A
HGNC ID
HGNC:9275
ORF Size (aa)
1149
ORF Size (bp)
1149 bp
RefSeq ID
NM_021003
RefSeq Synonyms
NM_177952, NM_177951, NM_021003, BC063243, BC026691,
Species
human
UniGene ID
Hs.130036

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.