T-cell factor 4 Adenovirus

Name 
Ad-TCF4
Cat No 
1401
Availability
Immediate
Categories
Adenovirus, Over-Expression

T-cell factor (TCF-1) and lymphoid enhancer-binding factor (for LEF-1, also designated TCF-1?) compose a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. LEF-1, TCF-1, and two other family members, TCF-3 and TCF-4, directly bind to cytosolic beta-catenin and facilitate its translocation to the nucleus, where these complexes induce expression of Wnt target genes.

1401
Ad-TCF4

Ready-to-use T-cell factor 4 Adenovirus. Ad-TCF4, T-cell factor 4 , E2-2,ITF2,SEF2,TCF4,SEF2-1,SEF2-1A,SEF2-1B adenovirus 1401

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
bHLHb19; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4
Description (Vector)
TCF4 encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. TCF4 is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described.
Gene ID
6925
Gene Name (Vector)
transcription factor 4
Gene Symbol
TCF4
HGNC ID
HGNC:11634
ORF Size (aa)
2004
ORF Size (bp)
2004 bp
RefSeq ID
NM_003199
RefSeq Synonyms
NM_003199, NM_001330605, NM_001330604, NM_001306208, NM_001306207, NM_001243236, NM_001243235, NM_001243234, NM_001243233, NM_001243232, NM_001243231, NM_001243230, NM_001243228, NM_001243227, NM_001243226, NM_001083962, BC125085, BC125084, BC031056,
Species
human
UniGene ID
Hs.605153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.