Wilms tumor 1 Adenovirus
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm’s tumors.
1398
Ad-WT1
Ready-to-use Wilms tumor 1 Adenovirus. Ad-WT1, Wilms tumor 1, GUD,WT1,WAGR,WT33,WIT-2 adenovirus 1398
Gene Reference Data
Alternate Names
AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33
Description (Vector)
WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. WT1 exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Gene ID
7490
Gene Name (Vector)
Wilms tumor 1
Gene Symbol
WT1
HGNC ID
HGNC:12796
ORF Size (aa)
909
RefSeq ID
NM_024426
RefSeq Synonyms
NM_024426, NM_024424, NM_001198552, NM_001198551, NM_000378, BC032861,
Species
human
UniGene ID
Hs.591980
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.